{"product_id":"abcam-ab162170","title":"Abcam, ab162170, Recombinant Human TRBV5-4 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human TRBV5-4 protein is a Full Length protein, in the 1 to 308 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe TRBV5-4 also known as T-cell receptor beta variable 5-4 is a part of the T-cell receptor complex. It contributes to the antigen recognition and immune response function. This protein has a predicted molecular weight of around 13 kDa. TRBV5-4 is expressed in T-cells which are an important component of the adaptive immune system. Understanding the mechanical function of TRBV5-4 is important to elucidate how T-cells identify and respond to pathogens or other foreign substances.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRBV5-4 interacts with other segments of the T-cell receptor complex to mediate T-cell specificity and response. It plays a role in recognizing peptide antigens presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells. The process of antigen recognition is fundamental for initiating T-cell-mediated immune responses. By doing so TRBV5-4 contributes to the adaptive immune system's ability to distinguish between self and non-self molecules and mount appropriate immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe TRBV5-4's involvement is mainly in the T-cell receptor signaling pathway and the immune synapse formation. It serves as an important component in ensuring T-cell activation upon recognition of the antigen-MHC complex. The pathway involves interaction with several proteins including CD3 and ZAP70 which transduce the activation signal inside the T-cell. These interactions are important for successful signal propagation necessary for subsequent immune responses.\u003cbr\u003e\nMutations or alterations in TRBV5-4 expression can be associated with immune system-related conditions such as autoimmune diseases and certain types of cancer. For example its aberrant activity might contribute to the pathogenesis of autoimmune disorders by inappropriate T-cell activation. Additionally TRBV5-4 might link with proteins like the MHC molecules in influencing immune escape mechanisms in cancerous cells. Understanding such associations helps in exploring TRBV5-4 as a potential therapeutic target in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843970093225,"sku":"ab162170","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab162170","provider":"Iright","version":"1.0","type":"link"}