{"product_id":"abcam-ab163206","title":"Abcam, ab163206, Recombinant Human Transmembrane protein 30A","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Transmembrane protein 30A is a Human Full Length protein, in the 1 to 361 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9NV96,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTransmembrane protein 30A also known as TMEM30A has an important role in cellular function as a component of the cell membrane. It is a 31 kDa protein that facilitates the transportation of certain lipids from the outer to the inner leaflets of the plasma membrane functioning as a chaperone alongside other transporters. TMEM30A shows expression in various tissues with notable levels in the brain heart and kidney reflecting its diverse cellular roles in different organ systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTMEM30A is critical in maintaining lipid asymmetry in cell membranes. It acts within a larger complex with flippases such as ATP11 and ATP8 proteins enabling the efficient translocation of phospholipids. This activity affects membrane curvature and flexibility which is essential for cellular processes like vesicle formation endocytosis and maintenance of membrane integrity. Disruption in TMEM30A function can result in altered cellular homeostasis impacting cell viability and signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM30A plays a significant part in the phospholipid flipping pathway chiefly interacting with ATP11C in energizing the lipid translocation process. This pathway is fundamental for activities like signal transduction and apoptosis where these lipids serve as substrates or signaling molecules. The protein also interrelates with the calcium signaling pathway wherein altered phospholipid distribution can influence calcium ion channels therefore impacting cellular responses and homeostasis.\u003cbr\u003e\nTMEM30A has associations with neurological disorders and cardiovascular diseases. Disturbances in its function link closely with Alzheimer's disease where phosphatidylserine asymmetry is compromised affecting neuronal communication. TMEM30A is also relevant in the context of heart failure interacting with proteins like ATP8A1 where improper lipid transport can impair cardiac function. Dysregulation of these pathways due to TMEM30A mutations highlights its importance in maintaining physiological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843922710697,"sku":"ab163206","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab163206","provider":"Iright","version":"1.0","type":"link"}