{"product_id":"abcam-ab164305","title":"Abcam, ab164305, Recombinant Human EGFL8 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human EGFL8 protein is a Human Full Length protein, in the 1 to 293 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q99944,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEGFL8 also known as epidermal growth factor-like protein 8 is a protein encoded by the EGFL8 gene. This protein weighs approximately 57 kDa and is part of the epidermal growth factor (EGF) family characterized by the presence of EGF-like domains. EGFL8 is expressed in various tissues particularly in the central nervous system and developing organs. These domains facilitate the protein's role in cellular signaling as they can bind to receptors and influence cell growth and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEGFL8 interacts with other proteins to modulate diverse processes including neurodevelopment and organogenesis. It plays an important role in cell adhesion proliferation and migration by engaging with cell surface receptors. The protein may also exist in a complex with other extracellular matrix proteins further influencing its function in tissue architecture. Its regulatory function suggests a potential involvement in maintaining cellular environment and responding to growth signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nEGFL8 is significantly involved in signaling cascades that are important for developmental processes. Notably it participates in the MAPK\/ERK pathway where it influences cell cycle dynamics and differentiation. This pathway also involves other proteins such as Ras and MEK which convey signals from growth factor receptors to the nucleus. EGFL8 may also have interactions with the Notch signaling pathway which is essential for various developmental processes and cell fate determination.\u003cbr\u003e\nEGFL8 has implications in the progression of certain neurodevelopmental disorders and cancers. Its altered expression or mutations can affect normal development potentially contributing to conditions such as autism spectrum disorder and brain tumors. The protein may interact with other dysregulated proteins in these diseases including Notch signaling components and EGF receptor pathways further complicating disease mechanisms and clinical outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843969568937,"sku":"ab164305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab164305","provider":"Iright","version":"1.0","type":"link"}