{"product_id":"abcam-ab164813","title":"Abcam, ab164813, Recombinant Human UCN2\/SRP protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human UCN2\/SRP protein is a Human Full Length protein, in the 1 to 112 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96RP3,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as UCN2.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUCN2 also known as urocortin 2 or stresscopin-related peptide (SRP) is a peptide hormone with a molecular weight of approximately 5 kilodaltons. This protein is abundant in several tissues including skeletal muscle and the central nervous system. It acts through the corticotropin-releasing factor receptor 2 (CRF2R) which is where UCN2\/SRP exerts its effects. Due to its expression pattern UCN2\/SRP holds significance in coordinating responses to stress and energy regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUCN2\/SRP plays an important role in the modulation of cardiovascular function and energy homeostasis. It is part of a molecular complex with CRF2R initiating signaling that influences heart rate and blood pressure regulation. UCN2\/SRP impacts thermogenic regulation and glucose metabolism indicating its role in energy balance. By interacting with CRF2R UCN2 may modulate anxiety-related behavior and help to mitigate stress responses due to changes in physiological states.\u003cbr\u003e\nPathways\u003cbr\u003e\nUCN2\/SRP participates in the stress-response pathway and the metabolic regulation pathway. Through the stress-response pathway it helps mediate the body's adaptive response to physical and psychological stress impacting the hypothalamic-pituitary-adrenal axis. In metabolic regulation UCN2\/SRP works alongside proteins like corticotropin-releasing hormone (CRH) to control glucose levels and lipolysis. These pathways highlight the diverse influence of UCN2\/SRP in managing bodily responses to environmental changes.\u003cbr\u003e\nUCN2\/SRP has been linked to conditions such as heart failure and metabolic syndrome. Increased expression of UCN2\/SRP may provide protective effects in heart failure by enhancing cardiac output and reducing vascular resistance. In metabolic syndrome UCN2\/SRP is associated with improved insulin sensitivity and lipid profiles working in part through its interaction with CRH. Understanding these connections helps in developing therapeutic strategies that target UCN2\/SRP for the treatment of such disorders using techniques like 'anti-SRP antibodies' and their applications in clinical studies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843943321769,"sku":"ab164813","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab164813","provider":"Iright","version":"1.0","type":"link"}