{"product_id":"abcam-ab165200","title":"Abcam, ab165200, Recombinant Human PNAD protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PNAD protein is a Human Full Length protein, in the 1 to 310 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96AB6,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as NTAN1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Peripheral Node Addressin (PNAd) is a glycoprotein recognized by its role in lymphocyte homing to lymph nodes. It is an important ligand for L-selectin on leukocytes facilitating their entry into lymphoid tissues. The PNAd marker is primarily located on the high endothelial venules (HEVs) where it guides lymphocyte trafficking. PNAd's molecular weight varies depending on its glycosylation patterns but is generally documented around 50 to 90 kDa.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPNAd mediates the adhesion of lymphocytes to HEVs a critical step in the immune response promoting the recirculation of lymphocytes throughout the body. PNAd does not function as an independent entity often part of a multiprotein complex involving various glycoproteins and ligands that collectively ensure efficient immune surveillance. Its interaction with L-selectin is an essential event in lymphocyte adhesion under shear flow conditions seen in blood circulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nPNAd plays a role in the lymphocyte signaling pathways particularly associated with leukocyte extravasation. This pathway is integral for lymphocyte migration involving key signaling molecules and interactions with proteins like ICAM-1 and VCAM-1. PNAd's function in this pathway reflects its importance for maintaining effective immune system balance and proper lymphocyte distribution.\u003cbr\u003e\nPNAd has involvement in inflammatory conditions such as rheumatoid arthritis and various lymphomas where aberrant lymphocyte trafficking occurs. In rheumatoid arthritis unusual PNAd expression on inflamed venules can lead to inappropriate lymphocyte accumulation in joints. Similarly in some lymphomas altered PNAd expression may associate with changes in lymphocyte migration patterns. Its interaction with proteins such as L-selectin occurs more frequently in these pathologies often exacerbating disease profiles.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843941650601,"sku":"ab165200","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab165200","provider":"Iright","version":"1.0","type":"link"}