{"product_id":"abcam-ab168453","title":"Abcam, ab168453, Anti-MAFG antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal MAFG antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MAFG.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human MAFG.O15525\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMAFG also known as MAFG transcription factor is a small basic leucine zipper (bZIP) protein that weighs approximately 18 kDa. It belongs to the small MAF protein family and has a role in gene regulation. MAFG is widely expressed in various tissues but shows higher expression in the liver and lungs. Functionally MAFG acts as a transcriptional repressor by binding to Maf recognition elements (MAREs) in the DNA regulating genes involved in cellular stress responses and homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe MAFG transcription factor forms complexes with other small MAF proteins like MAFF and MAFK or larger bZIP proteins. These complexes modulate transcription of antioxidant response genes such as those encoding phase II detoxifying enzymes. MAFG is important for the regulation of oxidative stress genes. The interaction of MAFG with other proteins determines whether it functions as a repressor or an activator influencing cellular responses to various stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nMAFG plays an important role in the oxidative stress response and the Nrf2 signaling pathway. It interacts closely with Nrf2 an important transcription factor activating the expression of antioxidant proteins to protect against oxidative damage. MAFG and Nrf2 along with other proteins facilitate cellular defense mechanisms by maintaining redox balance and regulating detoxification processes.\u003cbr\u003e\nMAFG links to conditions such as cancer and neurodegenerative diseases. Aberrant expression of MAFG may contribute to tumor development and progression by disrupting cellular homeostasis and detoxification pathways. Additionally MAFG dysregulation can affect the Nrf2 pathway impacting neurodegenerative disorders like Alzheimer's disease. Therefore understanding MAFG's interaction with Nrf2 and other proteins can provide insights into therapeutic strategies targeting these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852272783529,"sku":"ab168453","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab168453","provider":"Iright","version":"1.0","type":"link"}