{"product_id":"abcam-ab168852","title":"Abcam, ab168852, Anti-FXR2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal FXR2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FXR2 aa 600-650.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human FXR2 aa 600-650. The exact immunogen used to generate this antibody is proprietary information.P51116\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab168852 was affinity purified using an epitope specific to FXR2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein FXR2 also known as Fragile X Mental Retardation Syndrome-Related Protein 2 is part of the fragile X-related family of proteins. It has a molecular mass of approximately 78 kDa. This protein is expressed in various tissues with higher levels in the brain and testes. FXR2 acts primarily as an RNA-binding protein and has functional RNA transport and translational repression roles. The protein contains several motifs including a KH domain and RGG boxes which aid its interaction with RNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFXR2 is a part of a larger complex that includes homologous proteins like FMRP and FXR1. These proteins cooperate in the regulation of mRNA dynamics in neurons thereby playing essential roles in synaptic function and plasticity. They affect the translation of specific mRNAs and modulate the structure of dendritic spines. The FXR2 protein is important in the proper development of neurological architecture and cognitive processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nFXR2 participates in the mTOR signaling pathway and the regulation of dendritic translation. The mTOR pathway is vital for cell growth and protein synthesis critical in neural activity and development. FXR2 works alongside related proteins such as FMR1 and FXR1 within these pathways and these interactions modulate ribosome biogenesis and activity. FXR2 interactions importantly facilitate enhanced responses to synaptic activities.\u003cbr\u003e\nFXR2 influences conditions like Fragile X syndrome and autism spectrum disorders. Aberrations in FXR2 expression or function disrupt neuronal development and synaptic plasticity and are linked to cognitive impairments. FXR2 shares close connections with proteins FMR1 and CYFIP1 within these disorders suggesting a broader network of protein interactions critical for normal neurological function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848613220521,"sku":"ab168852","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab168852","provider":"Iright","version":"1.0","type":"link"}