{"product_id":"abcam-ab169045","title":"Abcam, ab169045, Anti-sPLA2-IIE antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal sPLA2-IIE antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PLA2G2E.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human PLA2G2E.Q9NZK7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSecretory phospholipase A2 group IIE (sPLA2-IIE) is an enzyme belonging to the phospholipase A2 family also known as PLA2G2E. It has a molecular mass of approximately 14 kDa. sPLA2-IIE hydrolyzes the sn-2 position of glycerophospholipids releasing free fatty acids and lysophospholipids. This enzyme shows expression in various tissues including the pancreas and inflammatory sites where it contributes to lipid metabolism and cell membrane remodeling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSecretory phospholipase A2 group IIE plays a role in inflammation and immune responses. Its activity results in the production of arachidonic acid and lysophospholipids which are precursors for eicosanoids like prostaglandins and leukotrienes. These lipid mediators regulate inflammatory processes thereby altering cellular responses. sPLA2-IIE participates in a complex network of enzymes and receptors modulating lipid signaling and affecting diverse physiological functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSPLA2-IIE interacts within the arachidonic acid pathway and the eicosanoid biosynthesis pathway. In these pathways sPLA2-IIE generates bioactive lipids impacting inflammatory signaling. It functions alongside proteins such as cyclooxygenase (COX) and lipoxygenase (LOX) which further metabolize arachidonic acid into specific eicosanoids. These pathways illustrate the enzyme's contribution to finely tuning the inflammatory response and cellular signaling networks.\u003cbr\u003e\nSecretory phospholipase A2 group IIE associates with conditions like rheumatoid arthritis and atherosclerosis. Its enzymatic activity correlates with the inflammatory components of these diseases promoting tissue damage and disease progression. Through its involvement in lipid mediator synthesis sPLA2-IIE interacts with proteins like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) key players in the inflammatory pathways that drive these disorders. Understanding the role of sPLA2-IIE in these diseases can help develop targeted therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852276551849,"sku":"ab169045","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab169045","provider":"Iright","version":"1.0","type":"link"}