{"product_id":"abcam-ab171093","title":"Abcam, ab171093, Anti-eIF2B3 antibody [1H3]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal eIF2B3 antibody. Suitable for IP, WB, IHC-P, ICC\/IF and reacts with Human, Rat, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EIF2B3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:1H3,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human, African green monkey,\u003cbr\u003e\nApplications:IP, WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human EIF2B3.Q9NR50\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEIF2B3 also known as eukaryotic translation initiation factor 2B subunit gamma plays an important role in the regulation of protein synthesis. It is part of the eIF2B complex a guanine nucleotide exchange factor for eIF2 which is critical in the initiation phase of mRNA translation. The eIF2B3 subunit has a molecular mass of approximately 58 kDa. This protein is ubiquitously expressed in various tissues reflecting its essential role in maintaining cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe eIF2B complex that includes eIF2B3 operates as a critical regulator in the synthesis of proteins by mediating the exchange of GDP for GTP on eIF2. This regulation affects the initiation of mRNA translation during cellular stress responses. The eIF2B complex consisting of five subunits including eIF2B3 facilitates the recycling of eIF2 essential for continued protein translation under normal conditions. This subunit's interactions within the complex are pivotal for modulating translational control mechanisms in response to environmental signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of eIF2B3 appears central to the integrated stress response (ISR) pathway influencing the translational control under diverse stress conditions like nutrient deprivation or viral infections. It connects primarily with eIF2 which when phosphorylated binds strongly to eIF2B inhibiting the guanine nucleotide exchange activity essential for protein synthesis progression. The ISR pathway's regulation of protein synthesis is key for the cellular adaptation during metabolic stress highlighting eIF2B3's significance in maintaining homeostasis.\u003cbr\u003e\nAltered eIF2B3 function is associated with Vanishing White Matter Disease (VWMD) a leukodystrophy affecting the central nervous system. Mutations in eIF2B3 and other subunits of the eIF2B complex can impair the guanine nucleotide exchange activity leading to reduced replenishment of functional eIF2 and compromised stress response adaptation. The consequential protein synthesis defects contribute to the pathogenesis of VWMD linking eIF2B3 malfunction to this disorder's progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854634406057,"sku":"ab171093","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab171093","provider":"Iright","version":"1.0","type":"link"}