{"product_id":"abcam-ab173282","title":"Abcam, ab173282, Anti-CELF-6 antibody [EPR10155]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CELF-6 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10155,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCELF-6 also known as CUGBP Elav-like family member 6 is a protein with a mass of approximately 55 kDa. This protein is part of the CELF family which includes members like CELF-5. CELF-6 is mainly expressed in the brain and plays roles involving post-transcriptional regulation of gene expression. It functions through binding RNA elements specifically regulating alternative splicing mRNA editing and translation. This protein significantly impacts RNA processing events helping maintain proper cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCELF-6 participates in controlling neuronal cell differentiation and function. It acts as a dynamic RNA-binding protein that can form part of larger ribonucleoprotein complexes influencing the fate of specific mRNAs. Through regulation of mRNA splicing and stability CELF-6 ensures that neurons develop and function properly. Studies have noted its substantial role in brain development where it affects the expression of genes essential for neuronal pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nCELF-6 influences post-transcriptional gene expression in neural tissues. CELF-6 is significantly involved in the MBNL1-mediated alternative splicing pathway and is known to modulate splicing activities. Its role overlaps with proteins like CELF which also participate in splicing and RNA processing regulation. The interactions between CELF proteins within these pathways highlight complex regulatory networks essential for proper RNA metabolism and neural function.\u003cbr\u003e\nCELF-6 has been linked to neurodevelopmental disorders specifically autism spectrum disorder (ASD). Abnormal expression or function of CELF-6 can lead to disrupted neural gene expression linked to ASD. Comparisons with other CELF proteins especially CELF-1 underline their collective influence on neural health. Furthermore CELF-6 alterations have been associated with epilepsy suggesting its critical role in neural excitability and signaling. Studies continue to explore the extent to which CELF-6 and its interactions contribute to the pathophysiology of such disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850224980137,"sku":"ab173282","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab173282","provider":"Iright","version":"1.0","type":"link"}