{"product_id":"abcam-ab173297","title":"Abcam, ab173297, Anti-NCAM2 antibody [EPR12815(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NCAM2 antibody. Suitable for IHC-P, IP, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12815(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNCAM2 also called Neural Cell Adhesion Molecule 2 is a protein that facilitates cell–cell adhesion mainly in the nervous system. It belongs to the immunoglobulin superfamily and has a mass of approximately 100 kDa. This protein is present in several tissues with high expression in the brain particularly within the hippocampus and olfactory bulb. It plays an important role in the organization of synapses and neural circuit formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNCAM2 functions as a cell adhesion molecule important for neurite outgrowth and synaptic plasticity. It does not operate alone; instead it participates in complexes with other neural cell adhesion molecules contributing to the assembly and stabilization of synaptic junctions. The protein assists neurons in maintaining their connections and supports brain development and neuroplastic changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nNCAM2 gets involved in both the MAPK and the PI3K-Akt signaling pathways which are essential for cell survival and growth. In these pathways NCAM2 interacts with proteins like FGF receptors and integrins facilitating the activation of downstream signaling cascades. The regulation of these pathways directly influences neuronal growth and differentiation highlighting its importance in the nervous system.\u003cbr\u003e\nDisruptions in NCAM2 function affect conditions such as autism spectrum disorder and Alzheimer's disease. Its role in synaptic connectivity links it to cognitive and developmental disorders. In Alzheimer's disease NCAM2 connections to amyloid precursor protein processing suggest its involvement in plaque formation. Changes in NCAM2 expression and its interaction with beta-amyloid pathogenesis could contribute to synaptic dysfunction in neurodegenerative diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850390917289,"sku":"ab173297","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab173297","provider":"Iright","version":"1.0","type":"link"}