{"product_id":"abcam-ab173528","title":"Abcam, ab173528, Anti-EF-Ts antibody [EPR12034]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal EF-Ts antibody. Suitable for IP, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12034,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEF-Ts also known as Elongation Factor Ts is a protein with a molecular mass of approximately 30 kDa. It plays a significant role in protein synthesis specifically during the elongation phase of translation. EF-Ts is a guanine nucleotide exchange factor and primarily expressed in prokaryotic cells aiding EF-Tu in the exchange of GDP for GTP. By this function EF-Ts maintains a continuous supply of active EF-Tu essential for protein translation efficiency.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEF-Ts facilitates the regeneration of its partner EF-Tu supporting its function in the ribosome. This protein forms part of the elongation factor complex an essential component of the translation machinery in bacterial cells. EF-Ts ensures EF-Tu remains in its active form enabling the delivery of aminoacyl-tRNA to the ribosomal A-site. Without EF-Ts EF-Tu would remain GDP-bound hampering protein synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nEF-Ts contributes to the translational control pathway by interacting directly with EF-Tu and ribosomes. It's important for maintaining the fidelity and speed of protein synthesis. EF-Ts operates alongside these components in the protein synthesis pathway which is central to cellular function and growth. EF-Ts does not work in isolation but coordinates closely with these other translational factors to maintain efficient protein production.\u003cbr\u003e\nDysfunctions in protein synthesis involving EF-Ts have implications for bacterial infections and antibiotic resistance. EF-Ts can be a target for antibiotics that aim to disrupt bacterial translation. Additionally studies have shown that mutations or alterations in related proteins like EF-Tu may lead to antibiotic resistance making EF-Ts a significant protein in understanding and combating bacterial diseases. Understanding EF-Ts' precise role offers insights into novel therapeutic approaches against these infections.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844191408297,"sku":"ab173528","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab173528","provider":"Iright","version":"1.0","type":"link"}