{"product_id":"abcam-ab174661","title":"Abcam, ab174661, Anti-RPS14 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal RPS14 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human RPS14 aa 100 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human RPS14 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P62263\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab174661 was affinity purified using an epitope specific to RPS14 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRibosomal Protein S14 (RPS14) also known as 40S ribosomal protein S14 plays an important mechanical role in ribosome assembly. This protein is a component of the small 40S subunit of the ribosome and has a molecular mass of approximately 17 kDa. RPS14 is expressed in various tissues reflecting its importance in general protein synthesis. Its expression in these tissues ensures that the ribosomes can function efficiently to translate mRNA into proteins a necessary process for cellular function and growth.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPS14 contributes to ribosome biogenesis and is essential for proper ribosome function. It is part of the ribosomal complex and interacts with ribosomal RNA (rRNA) to help assemble the small subunit of the ribosome. This ensures that the ribosome can accurately process genetic information into polypeptides. The protein's biological role reflects its contribution to maintaining cellular homeostasis and supporting cellular growth through effective protein production.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPS14 has roles in pathways that are important for protein synthesis and cell cycle progression. It plays a part in the ribosome biogenesis pathway which is related to the production and processing of rRNA and works with other ribosomal proteins like RPS19. Additionally it is involved in the p53 signaling pathway where it interacts with proteins that regulate the cell cycle and apoptosis emphasizing its importance in cellular response to stress or damage.\u003cbr\u003e\nAlterations in RPS14 are linked to specific blood conditions such as myelodysplastic syndromes especially those with deletion of chromosome 5q (5q- syndrome). The protein's alteration affects ribosome function and subsequently protein synthesis. This connection to 5q- syndrome involves interactions with other proteins such as RPS19 which also plays a role in ribosomal activities. Understanding RPS14’s impact on diseases aids in exploring therapeutic targets for related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855824867497,"sku":"ab174661","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab174661","provider":"Iright","version":"1.0","type":"link"}