{"product_id":"abcam-ab179802","title":"Abcam, ab179802, Anti-HSPC150\/UBE2T antibody [EP9447]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HSPC150\/UBE2T antibody. Suitable for IP, Flow Cyt (Intra), WB, ICC\/IF and reacts with Human samples. Cited in 6 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP9447,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe production method for this product has been changed from hybridoma to recombinant on 15th April 2024.\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHSPC150 also known as UBE2T is a protein involved in the ubiquitination process. It functions as a ubiquitin-conjugating enzyme essential for tagging proteins with ubiquitin marking them for degradation via the proteasome. UBE2T has a mass of approximately 22 kDa and shows expression in various tissues with higher levels found in the testis and bone marrow. It is critical in maintaining protein homeostasis by regulating the turnover of proteins within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHSPC150\/UBE2T interacts with the Fanconi anemia (FA) complex playing a significant role within DNA repair processes. Its activity is necessary for mono-ubiquitination of the FANCD2 protein a central component of the FA pathway. Through this engagement UBE2T contributes to the repair of interstrand crosslinks in DNA therefore supporting the maintenance of genomic integrity. The protein's involvement in these processes highlights its importance in preserving proper cellular functions and preventing genomic instability.\u003cbr\u003e\nPathways\u003cbr\u003e\nHSPC150\/UBE2T is mainly involved in the DNA damage repair pathways particularly the Fanconi anemia pathway. In this context it collaborates with proteins like FANCL and RAD51 which are key players in homologous recombination and DNA repair. Ubiquitination of FANCD2 by UBE2T integrates into these pathways facilitating efficient DNA repair and ensuring cell survival following genotoxic stress.\u003cbr\u003e\nDysfunction of HSPC150\/UBE2T links to cancer particularly with certain hematological malignancies. Alterations or overexpression of UBE2T can lead to defective DNA repair contributing to carcinogenesis due to accumulation of DNA damage. Furthermore associations with Fanconi anemia also illustrate its vital role given that mutations affecting UBE2T can hinder the pathway's function leading to bone marrow failure and increased cancer risk. The interaction with FANCD2 emphasizes its potential impact in conditions associated with genomic instability.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850277900457,"sku":"ab179802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab179802","provider":"Iright","version":"1.0","type":"link"}