{"product_id":"abcam-ab180583","title":"Abcam, ab180583, Anti-CHCHD1 antibody [EPR12253(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CHCHD1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12253(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCHCHD1 also known as Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1 is a protein with a molecular mass of approximately 13 kDa. It is localized mainly in the mitochondria where it plays an important role in maintaining mitochondrial function. Expression of CHCHD1 is found in various tissues with an increased presence in the heart skeletal muscle and brain which indicates its functional relevance in these energy-demanding tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe coiled-coil structure of CHCHD1 participates in protein-protein interactions within the cell. It is a component of a larger protein complex in the mitochondrial intermembrane space which assists in maintaining the stability and function of mitochondrial proteins. CHCHD1 contributes to the regulation of mitochondrial biogenesis and dynamics affecting cellular energy production and overall metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies show that CHCHD1 is involved in the mitochondrial oxidative phosphorylation pathway. It assists in regulating electron transport chain efficiency influencing ATP production. CHCHD1 also interacts with cytochrome c an important player in the electron transport chain highlighting its role in energy metabolism. These interactions ensure cells produce enough energy to support vital functions.\u003cbr\u003e\nResearch connects CHCHD1 to neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis (ALS). Altered CHCHD1 function can disrupt mitochondrial homeostasis contributing to the pathophysiology of these conditions. Interaction with proteins such as alpha-synuclein in Parkinson's or SOD1 in ALS links CHCHD1 to these disorders emphasizing its importance in disease progression and as a potential target for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850432729257,"sku":"ab180583","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab180583","provider":"Iright","version":"1.0","type":"link"}