{"product_id":"abcam-ab181469","title":"Abcam, ab181469, Anti-CD90 \/ Thy1 antibody [7E1B11]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nAnti-CD90 \/ Thy1 antibody [7E1B11] (ab181469) is a mouse monoclonal antibody detecting CD90 \/ Thy1 in  Western Blot, IHC-P, ICC\/IF . Suitable for  Human, Rat, . - KO validated for confirmed specificity - Over 20 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:7E1B11,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human THY1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P04216\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-CD90 \/ Thy1 antibody [7E1B11] (ab181469) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Rat, samples.\u003cbr\u003e\nWhat is the molecular weight of CD90 \/ Thy1?\u003cbr\u003e\nAnti-CD90 \/ Thy1 [7E1B11] (ab181469) specifically detects a band for CD90 \/ Thy1 (UniProt: P04216) at a molecular weight of 17kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-CD90 \/ Thy1 [7E1B11] (ab181469) was first used in a scientific publication in 2013 and has been cited over 20 times in peer-reviewed journals.\u003cbr\u003e\nSpecificity confirmed\u003cbr\u003e\nThe specificity of Anti-CD90 \/ Thy1 antibody [7E1B11] (ab181469) has been confirmed by Western blot testing in THY1 Knockout U2OS cell line,\u003cbr\u003e\nab262490\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD90 also known as Thy1 is a glycoprotein with a molecular mass of approximately 25-37 kDa. It is highly conserved across species and found on the surface of various cell types including fibroblasts neurons and endothelial cells. CD90 is expressed in these cells in tissues such as the brain thymus and lungs. Researchers use anti-CD90 antibodies for detection often in combination with CD90 FITC in immunofluorescence assays. CD90 serves as a useful cell marker particularly in identifying mesenchymal stem cells (MSCs).\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD90 plays a role in cell-cell and cell-matrix interactions contributing to cellular adhesion migration and signal transduction. It functions as part of a complex involving integrins which mediate its interaction with the extracellular matrix. This protein also influences T-cell activation reflecting its importance in immune response regulation. Its presence aids in modulating response to injury and promoting tissue repair due to its association with stem and progenitor cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD90 engagement affects focal adhesion and MAPK signaling pathways. It interacts with integrins like αvΒ3 and α5Β1 influencing cell movement and proliferation processes. CD90 involvement in these pathways allows it to regulate responses important for cell survival and communication within various tissues. These interactions highlight the protein's role in maintaining cellular homeostasis and regulating physiological processes.\u003cbr\u003e\nCD90 has associations with fibrosis and cancer. In fibrotic conditions CD90 expression affects fibroblast activity influencing tissue scarring in organs such as the liver and lungs. In cancer CD90 modifies tumor progression and metastasis by impacting cell adhesion and migration with connections to proteins like TGF-beta which further drive these processes. Understanding CD90 in disease contexts facilitates the development of therapeutic strategies aimed at modulating its activity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848216039593,"sku":"ab181469","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab181469","provider":"Iright","version":"1.0","type":"link"}