{"product_id":"abcam-ab182163","title":"Abcam, ab182163, Anti-KLHL6 antibody [EPR13484]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal KLHL6 antibody. Suitable for IP, WB, ICC\/IF and reacts with Human, Transfected cell line - Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13484,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKLHL6 also known as Kelch-like protein 6 is a member of the Kelch-like family of proteins. It plays a mechanistic role in protein-protein interactions mainly by acting as a substrate recognition component of an E3 ubiquitin ligase complex. KLHL6 has a molecular mass of approximately 52 kDa. This protein is primarily expressed in B cells and it is most abundant in the germinal center B cells within the lymphoid tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKLHL6 contributes to the regulation of B cell maturation and differentiation. Research indicates that KLHL6 is part of a Cul3-based E3 ubiquitin ligase complex which involves protein degradation processes. By functioning in this complex KLHL6 interacts with other proteins to ensure proper B cell development and immune responses. This function is important for maintaining normal immune system activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nKLHL6 plays a significant role in the B cell receptor (BCR) signaling pathway. This pathway is essential for B cell activation and differentiation. KLHL6 is associated with other pathway-related proteins such as BCR components and signaling molecules downstream in the pathway. Another key biological pathway involving KLHL6 is the ubiquitin-proteasome system which regulates protein turnover and influences various cellular processes by targeting proteins for degradation.\u003cbr\u003e\nKLHL6 alteration has been linked to certain B cell malignancies such as chronic lymphocytic leukemia (CLL). Its expression levels or mutations might influence the progression of these diseases. The protein is also connected with other ubiquitin-proteasome pathway components such as the Cul3 E3 ligase complex which might affect these disorders' development. Understanding KLHL6's role in these contexts can provide insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844188786857,"sku":"ab182163","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab182163","provider":"Iright","version":"1.0","type":"link"}