{"product_id":"abcam-ab182564","title":"Abcam, ab182564, Anti-POLD3 antibody [EP9480]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal POLD3 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP9480,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPOLD3 also known as DNA polymerase delta subunit 3 has an important role in DNA replication and repair. It acts as a regulatory subunit of the DNA polymerase delta complex which is responsible for high-fidelity DNA synthesis. The protein weighs approximately 57 kDa and shows expression in various tissues indicating its widespread role in the body.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe DNA polymerase delta complex includes POLD3 which helps in DNA replication and repair processes. POLD3 supports the polymerase activity improving the fidelity and stability of the DNA polymerase delta holoenzyme during DNA synthesis. POLD3’s presence in the polymerase delta complex allows it to be integral in ensuring accurate DNA duplication making it an important participant in genomic maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe DNA replication pathway prominently involves the action of POLD3. The protein participates in the DNA damage response pathway too contributing to the repair process. POLD3 interacts with other associated proteins in these pathways like the PCNA (proliferating cell nuclear antigen) enhancing the performance of DNA polymerase delta to achieve precise DNA synthesis and repair.\u003cbr\u003e\nAbnormal POLD3 function links to malignancies such as colorectal cancer. The mutations or changes in expression levels can affect the DNA replication fidelity promoting genomic instability. Additionally POLD3 connects with RAD9 another protein involved in the DNA damage checkpoint with alterations in these proteins being significant in the progression of specific cancers.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850273018025,"sku":"ab182564","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab182564","provider":"Iright","version":"1.0","type":"link"}