{"product_id":"abcam-ab182881","title":"Abcam, ab182881, Anti-Collagenase antibody - BSA and Azide free (Biotin)","description":"\u003cp\u003eSize: 1mL\u003cbr\u003e\nRabbit Polyclonal MMP1 antibody - conjugated to Biotin. Carrier free. Suitable for ICC, ELISA, Dot, WB, IHC-P and reacts with Clostridium histolyticum samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Clostridium histolyticum Collagenase.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Biotin,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Clostridium histolyticum,\u003cbr\u003e\nApplications:WB, ICC, Dot, IHC-P, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Clostridium histolyticum Collagenase.Q9X721\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 1mL, Purity-IgG fraction, Storage buffer-pH: 7.2 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle|Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCollagenase refers to a group of enzymes capable of breaking down collagen an important structural protein in the extracellular matrix. These enzymes including matrix metalloproteinase (MMP) family members like MMP-1 (also known as fibroblast collagenase) have molecular weights typically around 50-60 kDa. Collagenase enzymes can be expressed in various tissues such as skin cartilage and bone and also in fibroblasts and inflammatory cells. They play a significant role in remodeling and degrading extracellular matrix components which is essential for processes like tissue repair and development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese enzymes participate in collagen degradation allowing for cellular migration and growth by clearing path through the dense collagen network. Collagenase activity is carefully regulated because uncontrolled activity can lead to tissue damage and diseases. The enzymes do not function alone; they often form complexes or interact with inhibitors such as tissue inhibitors of metalloproteinases (TIMPs) which maintain the necessary balance in matrix remodeling. Researchers utilize collagenase inhibition assay techniques to study these interactions as well as to gauge enzyme efficiency and control.\u003cbr\u003e\nPathways\u003cbr\u003e\nCollagenase enzymes significantly contribute to the pathways of tissue remodeling and wound healing. They are involved in the matrix metalloproteinase pathway working with other MMPs like MMP-2 and MMP-9. In these pathways they collaborate with proteins such as elastase and stromelysin to degrade various matrix components. Balance between collagenase and TIMP proteins regulates these processes ensuring that tissue integrity is maintained during dynamic changes in the body.\u003cbr\u003e\nExcessive collagenase activity connects to arthritic disease and tumor metastasis. In arthritis there is an overproduction of collagenase particularly in joints which leads to the excessive breakdown of cartilage. Increased collagenase activity results as well in cancerous tumors enabling them to invade neighboring tissues. Various therapies target the regulation of collagenase and TIMP activity to mitigate tissue destruction and inhibit cancer progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848597262505,"sku":"ab182881","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab182881","provider":"Iright","version":"1.0","type":"link"}