{"product_id":"abcam-ab183021","title":"Abcam, ab183021, Anti-LLGL1 + LLGL2 antibody [EPR18899]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LLGL1 antibody. Suitable for IHC-P, ICC\/IF, IP, WB and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18899,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 53% identity (67% positives) with LLGL2. Cross-reactivity with this protein has not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe LLGL1 and LLGL2 proteins also known as Lethal (2) giant larvae proteins play important roles in cell polarity and asymmetric cell division. LLGL1 has a molecular mass of approximately 130 kDa and is expressed in various tissues with notable presence in the brain and reproductive organs. LLGL2 shares similar distribution and expression patterns. These proteins structurally contain several WD40 repeats involved in protein-protein interactions that help them in functioning as cortical factors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn epithelial cells and neural progenitors LLGL1 and LLGL2 are essential for maintaining cell polarity contributing to the structural stability and function of tissues. Both proteins are part of the Scribble complex a multi-protein assembly that regulates cell polarity and adhesion. By ensuring proper orientation and polarization of cells they are involved in tissue homeostasis and developmental processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nCell polarity and division control involves the LLGL1 and LLGL2 proteins. They are key components of the PAR (Partitioning-defective) pathway interplaying with proteins like aPKC and PAR-6 essential for spatial cellular orientation. Additionally they play a role in the Hippo signaling pathway which is important for organ size regulation and cell proliferation working alongside proteins such as YAP\/TAZ.\u003cbr\u003e\nDysfunction or alterations in LLGL1 and LLGL2 proteins have associations with cancer and neurological disorders. Loss of function can contribute to tumorigenesis highlighting their role as tumor suppressors in various cancer studies. In the context of neurological disorders improper regulation linked with these proteins can provide insight into brain development diseases interacting with proteins like Scribble and DLG variants.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850367488169,"sku":"ab183021","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab183021","provider":"Iright","version":"1.0","type":"link"}