{"product_id":"abcam-ab184124","title":"Abcam, ab184124, Anti-GTPBP4\/NOG1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GTPBP4\/NOG1 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GTPBP4 aa 250-600.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GTPBP4 aa 250-600. The exact immunogen used to generate this antibody is proprietary information.Q9BZE4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGTPBP4 also known as NOG1 is a highly conserved protein involved in ribosome biogenesis. The protein has a molecular mass of approximately 72 kDa. GTPBP4 is a GTP-binding protein which belongs to the circularly permuted GTPase (cpGTPase) family. It typically locates in the nucleolus where it is involved in ribosomal RNA processing and assembly of the large ribosomal subunit. Expression of GTPBP4 is widespread in human tissues indicating its important role in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe GTPBP4 protein contributes to the proper formation of the 60S ribosomal subunit through its role in ribosome assembly. It operates alongside other proteins as part of a complex. This role is important for maintaining normal levels of protein synthesis within cells. In particular GTPBP4 interacts with multiple ribosomal and nucleolar proteins to regulate ribosome assembly efficiently. Its activity ensures the structural maturation needed for the large subunit to join the small subunit during translation.\u003cbr\u003e\nPathways\u003cbr\u003e\nGTPBP4 is a part of the ribosome biogenesis pathway. This pathway is important for the production of ribosomal RNA and assembly of ribosomal components. GTPBP4 works in conjunction with proteins like NPM1 and other nucleolar components to maintain the fidelity of ribosome production. It also plays a role in ensuring that the ribosomal subunits are properly assembled and functional for mRNA translation therefore linking the biogenesis of ribosomes with protein synthesis pathways.\u003cbr\u003e\nAlterations in GTPBP4 expression or function can lead to various diseases such as cancer. GTPBP4 has connections to nucleolar stress responses which affect tumorigenesis. It interacts with proteins like MYC influencing cell proliferation and apoptosis. Dysregulation of GTPBP4 may disrupt ribosome biogenesis leading to imbalances in cell growth and division. It can also be involved in ribosomopathies disorders caused by defects in ribosome production impacting cellular protein synthesis and growth.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854157959337,"sku":"ab184124","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab184124","provider":"Iright","version":"1.0","type":"link"}