{"product_id":"abcam-ab184467","title":"Abcam, ab184467, Anti-SHCBP1 antibody [EPR18843]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SHCBP1 antibody. Suitable for IP, WB and reacts with Mouse, Rat, Human samples. Cited in 6 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18843,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSHCBP1 also known as SHC SH2-Domain Binding Protein 1 is a 72 kDa protein involved in cell cycle regulation. This protein exhibits a significant role in the interaction with the SHC1 adaptor protein influencing the signaling pathways activated by receptor tyrosine kinases. SHCBP1 shows high expression in tissues with active cell division such as the testis and several cancer cell lines. Its localization within cells includes both the cytoplasm and nucleus indicating diverse functional roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSHCBP1 aids in processes fundamental to cell proliferation and differentiation. It does not operate alone but participates in larger protein complexes that modulate cell division events. By interacting with other signaling molecules SHCBP1 becomes an important player in mitotic spindle assembly and cytokinesis. Its presence in complexes highlights its interaction with additional proteins which regulates the progression of the cell cycle.\u003cbr\u003e\nPathways\u003cbr\u003e\nSHCBP1 resides in pathways linked to the regulation of mitosis and cell proliferation. This protein plays an important role in the PI3K\/Akt signaling pathway which is pivotal for cell growth and survival. Additionally ties to proteins like PLK1 and Aurora B further emphasize SHCBP1's integration into cell cycle regulation networks. These interactions ensure proper cellular responses to growth signals and accurate chromosome segregation during mitosis.\u003cbr\u003e\nSHCBP1 connections to cancer and infertility are notable. In several types of cancer overexpression of SHCBP1 associates with tumor progression and poor prognosis often through its interaction with oncogenic proteins like Cyclin D1. In cases of male infertility dysregulation of SHCBP1 impacts spermatogenesis due to its essential role in cell cycle and division. Understanding these associations offers potential pathways for therapeutic interventions targeting SHCBP1-related mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850276753577,"sku":"ab184467","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab184467","provider":"Iright","version":"1.0","type":"link"}