{"product_id":"abcam-ab184674","title":"Abcam, ab184674, Anti-Alpha-synuclein (phospho S129) antibody [P-syn\/81A]","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-Alpha-synuclein (phospho S129) antibody [P-syn\/81A] (ab184674) is a mouse monoclonal antibody detecting Alpha-synuclein in  IHC-P . Suitable for  Human . - Over 30 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:P-syn\/81A,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SNCA phospho S129 aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P37840\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Alpha-synuclein (phospho S129) antibody [P-syn\/81A] (ab184674) is a mouse monoclonal antibody and is validated for use in IHC-P in human, mouse, rat samples.\u003cbr\u003e\nAnti-Alpha-synuclein (phospho S129) antibody [P-syn\/81A] (ab184674) has been cited over 31 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-Alpha-synuclein (phospho S129) antibody [P-syn\/81A] (ab184674) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Alpha-synuclein (phospho S129) antibody [P-syn\/81A] (ab184674) specifically detects Alpha-synuclein Phospho-S129 (Phospho-α-synuclein Ser129) (UniProt ID: P37840; Molecular weight: 14kDa) and is sold in 50 µL selling sizes.\u003cbr\u003e\nAlpha-synuclein phosphorylated at serine 129 (NACP\/SNCA pS129) is a post-translational modification of the alpha-synuclein protein, which is involved in synaptic function. Elevated levels of pS129 are found in the brains of individuals with Parkinson's disease and related disorders. This modification is linked to the aggregation of alpha-synuclein into Lewy bodies, which are pathological features of these diseases. Research suggests that pS129 may enhance the neurotoxic effects of alpha-synuclein, playing a critical role in the development and progression of neurodegenerative conditions.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlpha-synuclein often referred to by alternate names such as SNCA is a protein of around 14 kDa mass. It mainly expresses in the brain particularly in presynaptic nerve terminals. This protein functions mechanically by stabilizing synaptic vesicles and maintaining synaptic function. It exists both in soluble monomer forms and as aggregates in protein filaments. Antibodies like 4D6 and EP1536Y target monomer forms of protein for more detailed studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe alpha-synuclein protein plays critical roles in neuronal activity. It contributes to neurotransmitter release regulation by acting in the formation and plasticity of the presynaptic neuronal network. Alpha-synuclein doesn't usually form parts of large protein complexes but it may associate transiently with membranes and vesicular structures. The protein's monomer form has also been observed in alpha lines and related neuronal processes operating alongside various cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSynaptic vesicle trafficking and dopamine neurotransmitter release are significant areas involving the alpha-synuclein protein. In these pathways alpha-synuclein interacts with other proteins like synaptophysin and protein monomer monomerizations are intrinsic to these processes. Altered function or aggregation of alpha-synuclein disrupts these pathways influencing broader neurological functions.\u003cbr\u003e\nAlterations or accumulations of alpha-synuclein are strongly linked to Parkinson's disease and Lewy body dementia. In these conditions alpha-synuclein forms abnormal protein filaments known as Lewy bodies within neurons. These formations disrupt cellular processes and neuron health. Synucleinopathies such as these show connections with proteins like parkin and DJ-1 which also have key roles in these neurodegenerative diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845048586409,"sku":"ab184674","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab184674","provider":"Iright","version":"1.0","type":"link"}