{"product_id":"abcam-ab185704","title":"Abcam, ab185704, Anti-EPB41 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal EPB41 antibody. Suitable for WB, ICC\/IF and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EPB41 aa 200-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human EPB41 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.P11171\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein 4.1 also known as EPB41 plays an important role in maintaining the mechanical stability and elasticity of the erythrocyte membrane. This protein exists as a component of the erythrocyte membrane skeleton where it interacts with spectrin and actin contributing to the cytoskeletal network. It weighs approximately 80kDa. EPB41 expression is not limited to erythrocytes; it's found in various tissues including the brain and kidney which indicates its diverse functional roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein supports cell shape and mechanical properties by linking the cytoskeleton to the plasma membrane. EPB41 is involved in the membrane-cytoskeletal junctional complex where it interacts with other proteins such as spectrin and glycophorin C. This interaction is key in erythrocytes to prevent cell lysis under mechanical stress. Beyond its role in erythrocytes EPB41 assists in protein stabilization and localization within the plasma membrane in other cell types.\u003cbr\u003e\nPathways\u003cbr\u003e\nEPB41 plays an important part in the erythrocyte cell surface structure pathway as well as cell signaling pathways in non-erythroid cells. In the former EPB41 works closely with spectrin and actin to maintain the cellular integrity necessary for oxygen transport. Furthermore in cell signaling pathways its interaction with ankyrin influences membrane organization and signal transduction which are vital for diverse cellular functions.\u003cbr\u003e\nMutations or malfunctions in EPB41 correlate with conditions such as hereditary elliptocytosis and neurodegenerative disorders. Hereditary elliptocytosis results from defects in erythrocyte membrane proteins where EPB41 interplays with spectrin to contribute to the disorder. In neurodegenerative diseases alterations in EPB41 may affect brain tissue stability and function due to its role in sustaining membrane mechanics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854207799465,"sku":"ab185704","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab185704","provider":"Iright","version":"1.0","type":"link"}