{"product_id":"abcam-ab190226","title":"Abcam, ab190226, Anti-FOXL1 antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nRabbit Polyclonal FOXL1 antibody. Suitable for WB, IHC-P and reacts with Chinese hamster, Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FOXL1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human, Chinese hamster,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human FOXL1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q12952\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFOXL1 also known as Forkhead Box L1 is a transcription factor encoded [by the FOXL1 gene] and has a mass of approximately 38 kDa. This protein is part of the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXL1 is expressed mainly in the mesenchymal cells of the gastrointestinal tract particularly in the stomach and the small intestine. Additionally it can be found in other tissues but at lower levels contributing to its role in the regulation of various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe transcription factor FOXL1 plays a critical role in the development and differentiation of tissues within the digestive system. It functions as part of a complex that regulates mesenchymal-epithelial interactions during organogenesis particularly in the gut. FOXL1 influences the cell proliferation apoptosis and differentiation required for maintaining the homeostasis and architecture of the gastrointestinal epithelium. Its activity can modulate the expression of genes involved in the signaling pathways that are essential for tissue repair and development.\u003cbr\u003e\nPathways\u003cbr\u003e\nFOXL1 impacts the hedgehog signaling and the Wnt\/β-catenin pathway both of which are important to embryonic development and cell differentiation. In the hedgehog signaling pathway FOXL1 interacts with other proteins such as GLI transcription factors to modulate gene expression. Similarly the Wnt\/β-catenin pathway involves FOXL1 in regulating processes linked to cell growth and differentiation in the intestinal environment often working with proteins like TCF7L2 to control target gene transcription.\u003cbr\u003e\nFOXL1 has connections to gastrointestinal cancers and congenital disorders affecting the digestive tract. Anomalies in FOXL1 expression or function can contribute to the development of stomach cancer where it may act together with the aberrant activation of FOXO3 and CTNNB1 proteins. Additionally disruptions in the regulatory roles of FOXL1 can lead to disorders such as duodenal atresia as it is fundamental in proper gastrointestinal development and maintenance. FOXL1's involvement in these diseases highlights its significance in understanding the molecular mechanisms underlying gastrointestinal pathologies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854365872297,"sku":"ab190226","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab190226","provider":"Iright","version":"1.0","type":"link"}