{"product_id":"abcam-ab190232","title":"Abcam, ab190232, Anti-MRPL13 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal MRPL13 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MRPL13 aa 100 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MRPL13 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BYD1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMRPL13 also known as mitochondrial ribosomal protein L13 plays an important role in mitochondrial protein synthesis. It is a component of the mitochondrial ribosome large subunit (39S). The molecular mass of MRPL13 is approximately 18 kilodaltons. This protein is primarily expressed in tissues with high energy demands such as skeletal muscle heart and brain. MRPL13 functions within the mitochondrial matrix contributing to the assembly and stability of the ribosome.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMRPL13 facilitates the process of mitochondrial translation which is essential for the production of proteins encoded by the mitochondrial genome. MRPL13 forms part of the 39S subunit of the mitochondrial ribosome working alongside other ribosomal proteins to translate mitochondrial mRNAs. This activity is critical for the maintenance of mitochondrial function as mitochondria rely on their own protein synthesis machinery to support cellular energy production.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRPL13 plays a vital role in the oxidative phosphorylation pathway which is key for ATP production in cells. This pathway involves numerous proteins including cytochrome c oxidase and ATP synthase which work together to generate ATP from ADP. MRPL13 assists in the synthesis of mitochondrial components of oxidative phosphorylation ensuring efficient energy production. Its role in translation further connects MRPL13 to the regulation of mitochondrial biogenesis and energy metabolism within the cell.\u003cbr\u003e\nMRPL13 has been linked to mitochondrial dysfunction and syndromes characterized by impaired energy metabolism such as mitochondrial myopathy and Leigh syndrome. Abnormalities in MRPL13 affect the assembly and function of the mitochondrial ribosome disrupting ATP production and leading to clinical symptoms. This protein might interact with other mitochondrial ribosomal proteins like MRPS22 to influence disease progression. Understanding MRPL13's involvement in these conditions can aid in developing therapeutic strategies targeting mitochondrial bioenergetics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854365839529,"sku":"ab190232","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab190232","provider":"Iright","version":"1.0","type":"link"}