{"product_id":"abcam-ab190389","title":"Abcam, ab190389, Recombinant human Sps1\/Ste20 related kinase 4 protein","description":"\u003cp\u003eSize: 5µg \/ 10µg\u003cbr\u003e\nRecombinant human Sps1\/Ste20 related kinase 4 protein is a Human Fragment protein, in the 941 to 1328 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;80%, suitable for SDS-PAGE, WB, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;80% Densitometry,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab190389 was determined to be 38 nmol\/min\/mg.,\u003cbr\u003e\nAccession:Q56UN5,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.1% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab64311\u003cbr\u003e\n(Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSps1\/Ste20 related kinase 4 also known as STK4 or MST1 is a serine\/threonine kinase with a molecular mass of approximately 56 kDa. This kinase belongs to the Germinal Center Kinase (GCK) group of the STE20-like kinase family and it plays a significant role in signal transduction processes. STK4 is broadly expressed with prominent presence in tissues like the liver and pancreas. The protein localizes both in the cytoplasm and nucleus and is known to translocate in response to stress signals.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis kinase helps regulate apoptosis and cell proliferation. As a part of the Hippo signaling pathway STK4\/MST1 operates within a cascade of interactions involving multiple cellular proteins. It forms a complex with other proteins such as SAV1 and LATS1\/2 to execute control over organ size by modulating cell growth and apoptosis. Through these interactions STK4 maintains cellular homeostasis and prevents abnormal cellular developments such as overgrowth.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTK4 plays an integral part in the Hippo signaling and MAPK pathways. Within the Hippo pathway it partners with MST2 to phosphorylate downstream effectors which impacts transcription regulation and ultimately cellular proliferation and apoptosis. In the MAPK pathway STK4’s activities interface with those of the YAP and TAZ proteins further linking it to cellular signaling processes that control cell fate decisions.\u003cbr\u003e\nAberrant STK4 activity connects to cancer and neurodegenerative disorders. Its dysfunctional signaling in the Hippo pathway can lead to tumorigenesis especially when downregulation occurs reducing its inhibitory control over cell growth. In the context of neurodegenerative disorders altered STK4 activity associates with conditions like Alzheimer's disease where its interaction with tau protein influences tau phosphorylation and aggregation both hallmarks of the disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843829715113,"sku":"ab190389","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab190389","provider":"Iright","version":"1.0","type":"link"}