{"product_id":"abcam-ab190698","title":"Abcam, ab190698, Anti-XPB antibody [EPR14161]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal XPB antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14161,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nXPB also known as ERCC3 is part of the helicase family. It has an approximate mass of 89 kDa. XPB uses ATP to unwind DNA which facilitates various genetic processes. In humans it expresses in tissues where there is active DNA replication and repair occurring including rapidly dividing cells. Its activity is important to the transcription process and DNA damage repair mechanism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nXPB assists the cellular response to DNA damage by being part of the TFIIH complex which is involved in transcription. This complex plays a role in nucleotide excision repair (NER) where it unwinds DNA segments to allow for lesion repair. In conjunction with other proteins XPB facilitates the resolution of DNA loops and manages the clearance of polymerase during transcription-coupled repair ensuring proper DNA repair and transcription restart.\u003cbr\u003e\nPathways\u003cbr\u003e\nXPB influences both transcription initiation and DNA damage repair being integral to the mechanisms that maintain genome integrity. It interacts closely with proteins like XPD within the NER pathway and its roles in these pathways contribute to the prevention of mutations. XPB's function as a helicase denotes its participation in opening DNA for repair or transcription therefore supporting cell viability and genomic stability.\u003cbr\u003e\nXPB's deficiency or malfunction links to xeroderma pigmentosum and trichothiodystrophy. These conditions stem from impaired nucleotide excision repair where mutations in XPB affect the efficiency of DNA repair and proper cellular response to damage. Symptoms correlated with these diseases often include increased sensitivity to UV light and neurological deficits connected through pathways involving other TFIIH complex components like XPD signifying the collaboration needed within a cell for effective DNA repair.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844167094441,"sku":"ab190698","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab190698","provider":"Iright","version":"1.0","type":"link"}