{"product_id":"abcam-ab190715","title":"Abcam, ab190715, Anti-EPX antibody [AHE-1]","description":"\u003cp\u003eSize: 500µL\u003cbr\u003e\nMouse Monoclonal EPX antibody. Suitable for Flow Cyt, ICC\/IF, IHC-Fr and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Cell preparation containing EPX protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:AHE-1,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt, ICC\/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing EPX protein. The exact immunogen used to generate this antibody is proprietary information.P11678,\u003cbr\u003e\nSpecificity:ab190715 recognizes EPX. It does not cross-react with eosinophil major basic protein, elastase, cathepsin G, esterase N, thrombin, plasmin, kallikrein, lactoferrin, or transferrin. ab190715 stains eosinophils only and does not stain other peripheral blood cells, including platelets, neutrophils, monocytes, lymphocytes or red blood cells.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab190715 was purified from Bioreactor Concentrate., Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEPX also known as eosinophil peroxidase or e p x is an enzyme with a molecular mass of approximately 71 kDa. This enzyme is mainly expressed in eosinophils a type of white blood cell involved in the immune response. EPX is located in the granules of eosinophils and it plays a role in the catalysis of halide ions and hydrogen peroxide to produce hypohalous acids which are potent antimicrobial agents. These acids contribute to the killing of bacteria and other pathogens making the enzyme a critical component of the immune system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEosinophil peroxidase participates in the body's defense against parasitic infections and allergic reactions. It is not known to be a part of a larger protein complex but it does interact with other proteins within the immune response setting. EPX helps in generating reactive oxygen species which have antimicrobial properties and are important in immune signaling pathways. Although it can lead to tissue damage when overproduced its controlled activity is necessary for effective immune function.\u003cbr\u003e\nPathways\u003cbr\u003e\nEosinophil peroxidase's activity intersects with the respiratory burst pathway and the detoxification pathway. The enzyme contributes to the formation of reactive oxygen species in the respiratory burst pathway which is important for pathogen destruction. EPX is also connected with enzymes like myeloperoxidase (MPO) that function similarly in the immune response though EPX is more specific to eosinophils. This specialization makes it an important player in eosinophil-associated diseases and disorders.\u003cbr\u003e\nEosinophil peroxidase has links to asthma and allergic diseases. Its activity in producing reactive oxygen species and hypohalous acids can exacerbate airway inflammation in asthma resulting in tissue damage. Additionally EPX has been studied in the context of autoimmune conditions as its dysregulated activity may contribute to inflammation. Its interaction with other proteins like myeloperoxidase could also influence such diseases highlighting the enzyme's role in pathological processes beyond its beneficial antimicrobial functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860478120105,"sku":"ab190715","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab190715","provider":"Iright","version":"1.0","type":"link"}