{"product_id":"abcam-ab192649","title":"Abcam, ab192649, Anti-MERTK (phospho Y749) + TYRO3 (phospho Y681) antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MERTK phospho Y749 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 14 publications. Immunogen corresponding to Synthetic Peptide within Human MERTK phospho Y749.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MERTK phospho Y749. The exact immunogen used to generate this antibody is proprietary information.Q12866,\u003cbr\u003e\nSpecificity:ab192649 endogenous levels of MERTK only when phosphorylated at Tyrosine 749 and endogenous levels of TYRO3 only when phosphorylated at Tyrosine 681.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab192649 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibody was removed by chromatogramphy using non-phosphopeptide., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMERTK and TYRO3 are receptor tyrosine kinases that belong to the TAM (TYRO3 AXL MERTK) family. MERTK is often referred to as c-MERTK and TYRO3 as RSE or Sky. MERTK has a molecular weight of approximately 110 kDa and TYRO3 weighs around 105 kDa. MERTK and TYRO3 are mostly found in the immune system particularly in macrophages dendritic cells and also in retinal pigment epithelial cells. These receptors are important for regulating cellular processes including phagocytosis immunological homeostasis and tissue repair.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins play roles beyond membrane receptors and are pivotal for immune regulation and maintaining cell health. MERTK pairs with ligands such as Gas6 and Protein S leading to receptor-autophosphorylation and activating downstream signaling pathways. TYRO3 also operates in conjunction with similar ligands and both receptors form part of a complex that helps in cellular homeostasis and inflammation control. They contribute to processes like the apoptotic cell clearance which helps in resolving inflammation.\u003cbr\u003e\nPathways\u003cbr\u003e\nBoth proteins participate in significant signaling axes such as the PI3K\/AKT and MAPK pathways. These pathways are linked with cell survival proliferation and differentiation. MERTK activates these pathways upon binding with its ligands influencing immune functions and cellular repair. Alyso TYRO3 associates closely with Ras and Erk proteins which are central parts of these signaling cascades impacting cellular cycles and apoptosis.\u003cbr\u003e\nMERTK and TYRO3 have been implicated in conditions like cancer and autoimmune diseases. MERTK overexpression for instance correlates with tumor development and progression making it a target for cancer therapies. TYRO3's involvement in autoimmune diseases roots from its role in immune system modulation. By interacting with AXL another TAM family member both proteins influence conditions like leukemia and rheumatoid arthritis through their control over immune responses and cell survival mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854373998761,"sku":"ab192649","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab192649","provider":"Iright","version":"1.0","type":"link"}