{"product_id":"abcam-ab193728","title":"Abcam, ab193728, Mouse Renin 1 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nMouse Renin 1 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Mouse Renin 1 in Mouse in Biofluids, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Plasma, Cell culture supernatant, Serum,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 6 pg\/mL,\u003cbr\u003e\nRange:6 - 50000 pg\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAbcam's Renin 1 mouse ELISA kit (ab193728) is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse Renin 1 in serum, plasma and cell culture supernatants.\u003cbr\u003e\nThis assay employs an antibody specific for mouse Renin 1 coated on a 96 well plate. Standards and samples are pipetted into the wells and the immobilized antibody captures Renin 1 present in the sample. The wells are washed and biotinylated anti-mouse Renin 1 antibody is added. After washing away unbound biotinylated antibody, an HRP-conjugated streptavidin is pipetted into the wells. After incubation, the wells are again washed, followed by the addition of a TMB substrate solution to the wells. Color develops in proportion to the amount of Renin 1 bound in each well. Addition of the Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Renin Receptor also known as ATP6AP2 or the (pro)renin receptor is an important protein involved in the regulation of the renin-angiotensin system. It has a molecular mass of approximately 37 kDa. Expressed widely across several tissues including the kidneys heart and brain it acts by binding renin and prorenin leading to their activation and subsequent signaling. This receptor also facilitates cellular responses by increasing the efficiency of angiotensinogen conversion to angiotensin I which is a precursor to the potent vasoconstrictor angiotensin II.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Renin Receptor participates in maintaining homeostasis within the renin-angiotensin-aldosterone system. It potentially forms part of a larger receptor complex by interacting with other pathway components. By modulating the activity of renin and prorenin it enhances blood pressure regulation and fluid balance contributing to cardiovascular function and cellular ion homeostasis. Its involvement extends to promoting cell signaling events related to growth development and metabolism through the MAPK pathway.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Renin Receptor integrates into the renin-angiotensin system and the Wnt signaling pathway. In the renin-angiotensin system the receptor interacts with proteins such as angiotensin-converting enzyme (ACE) and angiotensin receptors playing an important role in blood pressure and electrolyte balance. Its engagement in the Wnt pathway suggests a role in development and cellular proliferation highlighting its interaction with proteins involved in cellular communication and embryonic development.\u003cbr\u003e\nThe Renin Receptor is linked to hypertension and cardiovascular diseases. Its overactivity or dysregulation may lead to elevated blood pressure due to increased angiotensin II formation. Additionally it is associated with heart failure where it contributes to pathological cardiac remodeling. The receptor's interaction with ACE and the renin-angiotensin system components highlights its involvement in these cardiovascular disorders suggesting potential targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843643199657,"sku":"ab193728","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab193728","provider":"Iright","version":"1.0","type":"link"}