{"product_id":"abcam-ab195977","title":"Abcam, ab195977, Anti-Forkhead box protein O\/dFOXO antibody - N-terminal","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Forkhead box protein O\/dFOXO antibody. N-terminal. Suitable for WB and reacts with Drosophila melanogaster samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Drosophila melanogaster foxo.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Drosophila melanogaster,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Drosophila melanogaster foxo. The exact immunogen used to generate this antibody is proprietary information.Q95V55\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 100µL, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris buffer, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nForkhead box protein O (FOXO) also known as dFOXO in Drosophila is a transcription factor notable for its role in regulating gene expression. FOXO proteins typically weigh between 70 and 80 kDa. They are widely expressed in various tissues including the liver pancreas and adipose tissue. Mechanically FOXO proteins can bind to DNA sequences and influence the transcription of genes involved in cell cycle regulation apoptosis and oxidative stress response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFOXO proteins are involved in multiple cellular processes that maintain homeostasis. When in the cytoplasm FOXO proteins stay inactive but they translocate to the nucleus when activated. They are not part of a large protein complex but their function can be influenced by interaction with other proteins such as Akt which phosphorylates and inactivates them. Once in the nucleus FOXO proteins facilitate the transcription of genes that handle metabolic regulation cell growth inhibition and longevity.\u003cbr\u003e\nPathways\u003cbr\u003e\nFOXO proteins play significant roles in the PI3K-Akt signaling and insulin signaling pathways. Within these pathways FOXO proteins act as key regulators often interacting with proteins like Akt which phosphorylates FOXO and leads to its exclusion from the nucleus. These pathways demonstrate how FOXO proteins integrate environmental signals to mediate cellular responses like stress resistance and metabolism regulation.\u003cbr\u003e\nFOXO proteins have associations with cancer and diabetes. Mutations or dysregulation of FOXO activity can contribute to tumor development by allowing unchecked cell proliferation. Similarly in diabetes impaired insulin signaling affects FOXO function leading to alterations in glucose metabolism. In cancer FOXO can interact with proteins like p53 while in diabetes its activity can influence insulin-responsive pathways showcasing its diverse role in disease dynamics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854415646889,"sku":"ab195977","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab195977","provider":"Iright","version":"1.0","type":"link"}