{"product_id":"abcam-ab196755","title":"Abcam, ab196755, Anti-IRX2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal IRX2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IRX2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human IRX2. The exact immunogen used to generate this antibody is proprietary information.Q9BZI1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab196755 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIRX2 also known as Iroquois Homeobox 2 is a transcription factor involved in embryonic development. It has a molecular mass approximately 49 kDa and is a member of the Iroquois homeobox gene family. IRX2 is expressed in several tissues including the developing nervous system and heart. It plays a role in pattern formation and cell differentiation during early embryonic stages.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIRX2 functions as an important regulator of the transcription process during development. It is part of a family of Iroquois genes that form protein complexes to influence gene expression patterns. These complexes contribute to the establishment of regional identity in the embryo. IRX2 impacts limb neural and cardiac tissue development by interacting with other transcription factors in these regions.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers have identified IRX2 as a participant in the Wnt signaling pathway and the Hedgehog pathway. These pathways are critical for the regulation of cell proliferation and differentiation. IRX2 interacts with proteins such as SHH (Sonic Hedgehog) and BMPR which are integral components in these pathways influencing developmental processes.\u003cbr\u003e\nEvidence links IRX2 to congenital heart defects and certain types of cancers. Malfunctions in IRX2 expression levels or activity may disrupt normal developmental processes leading to these conditions. IRX2 interacts with proteins such as GATA4 in cardiac-related pathologies which further emphasizes its role in heart development and disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854245613737,"sku":"ab196755","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab196755","provider":"Iright","version":"1.0","type":"link"}