{"product_id":"abcam-ab197246","title":"Abcam, ab197246, Anti-DEPDC1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal DEPDC1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DEPDC1 aa 1-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human DEPDC1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q5TB30\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDEPDC1 also known as DEP domain-containing protein 1 has a molecular weight of roughly 92 kDa. It primarily functions as a nuclear protein playing roles in cell cycle regulation and mitosis. DEPDC1 is found expressed in various tissues but its expression is notably high in certain cancer cells. This protein interacts with other cellular components within the nucleus indicating its involvement in important cellular processes related to proliferation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEPDC1 influences cell growth and division. It participates in the formation of complexes with other proteins which are essential for its role in mitotic progression. Through its interactions in these complexes DEPDC1 regulates key processes needed for proper cell cycle check and balance ensuring cells divide correctly. Moreover its levels can affect how tissues develop and regenerate considering its heightened activity during rapid cell division phases.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of DEPDC1 ties into significant cellular mechanisms like the cell cycle and Wnt signaling pathways. In the cell cycle DEPDC1 associates with various cyclins and cyclin-dependent kinases to modulate transition between different phases facilitating smooth progression through mitotic checkpoints. Furthermore in the Wnt signaling pathway it may impact how signals are transduced influencing cellular differentiation and development processes potentially interacting with proteins such as beta-catenin.\u003cbr\u003e\nDEPDC1 has clear associations with cancer and neurodegenerative diseases. In cancer its overexpression links to the uncontrolled cell growth seen in tumors interacting with proteins like p53 which are responsible for cell cycle arrest and apoptosis. In some neurodegenerative diseases irregularities in DEPDC1 functions can lead to improper neuronal cell cycle re-entry causing neurodegeneration. Its involvement in these pathologies makes it a notable target for research into therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854358565033,"sku":"ab197246","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab197246","provider":"Iright","version":"1.0","type":"link"}