{"product_id":"abcam-ab197315","title":"Abcam, ab197315, Anti-NELL1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal NELL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NELL1 aa 150-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human NELL1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.Q92832\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-Reconstitute in 200 ul sterile H2O., Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNELL1 also known as Neural EGFL Like 1 is a protein primarily involved in cell signaling processes. Its molecular weight is approximately 87 kDa. NELL1 expresses in tissues such as bone cartilage blood vessels and the nervous system. It functions as a secreted glycoprotein and may play a role in mediating cellular communication.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein influences cell growth differentiation and apoptosis. NELL1 is not known to be part of a multiprotein complex but it interacts with various factors that regulate tissue development. It has significant functions in osteogenesis and angiogenesis impacting bone formation and blood vessel formation. The presence of NELL1 is essential for normal skeletal development and repair.\u003cbr\u003e\nPathways\u003cbr\u003e\nMultiple molecular interactions involve NELL1 in critical signaling pathways. NELL1 acts in the BMP signaling pathway an important player in bone and cartilage development. It also interacts with TGF-beta signaling pathways which regulate cell proliferation and differentiation. These interactions link NELL1 to proteins like BMP2 and TGF-beta receptors highlighting its role in cellular signaling dynamics.\u003cbr\u003e\nNELL1 has associations with conditions like craniosynostosis and osteoporosis. Altered expression of NELL1 contributes to the premature fusion of skull bones in craniosynostosis. In osteoporosis NELL1 influences bone density and structure abnormalities. NELL1 also interacts with proteins such as RUNX2 which further contribute to the pathogenesis of these skeletal disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854373048489,"sku":"ab197315","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab197315","provider":"Iright","version":"1.0","type":"link"}