{"product_id":"abcam-ab19962","title":"Abcam, ab19962, Anti-Neisseria gonorrhoeae antibody","description":"\u003cp\u003eSize: 500µL\u003cbr\u003e\nRabbit Polyclonal Neisseria gonorrhoeae antibody. Suitable for ICC\/IF and reacts with Neisseria gonorrhoeae samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing Neisseria gonorrhoeae protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Neisseria gonorrhoeae,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Reacts to all antigens of Neisseria gonorrhoeae. Antiserum is not absorbed and may react with related microorganisms.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeisseria gonorrhoeae also known as gonococcus is a Gram-negative bacterium that mechanically plays an integral role in facilitating infections particularly in mucous membranes. This pathogen has a mass of approximately 1.0 giga daltons. Gonococcus is expressed in the extracellular regions of human host tissues primarily in the urogenital tract. It uses specialized pili to adhere to epithelial cells helping it colonize and invade host tissues making it an efficient pathogen for transmission and infection.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeisseria gonorrhoeae employs its numerous surface proteins to engage the host's defense mechanisms. One such important component is its ability to form a type IV pilus complex which assists in DNA uptake and nuancing of surface morphology. This bacterium also constitutes proteins like PorB a porin protein essential for nutrient uptake and immune evasion. By altering its surface structures through antigenic variation it adapts effectively to host immune responses. Gonococcal antibodies target these surface antigens to neutralize infection highlighting its complex interactions within the host.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeisseria gonorrhoeae shares essential roles in modulating signaling mechanisms within immune response pathways. The bacterium influences the complement pathway rendering it a critical focus for immune modulation to avoid opsonization. Another vital pathway includes the activation of the bacterial type III secretion system facilitating translocation of effector proteins into host cells. Proteins like Opa encountered frequently in these pathways interact closely with host cell receptors modulating host-cell communication to enhance bacterial survival.\u003cbr\u003e\nInfections caused by Neisseria gonorrhoeae characteristically lead to gonorrhea a common sexually transmitted disease. Beyond localized infection it can cause disseminated gonococcal infections if untreated. The pathogen's ability to alter surface proteins significantly contributes to antibiotic resistance complicating treatment strategies. Gonococcus interacts with proteins such as lactoferrin-binding protein which plays a role in iron acquisition a critical factor in the pathogenesis and persistence of athletic tendinopathy as well. The ongoing challenge of combatting antibiotic-resistant strains necessitates further understanding of its molecular mechanisms and relationships with host proteins.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854196887721,"sku":"ab19962","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab19962","provider":"Iright","version":"1.0","type":"link"}