{"product_id":"abcam-ab200550","title":"Abcam, ab200550, Anti-GTPBP1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GTPBP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GTPBP1 aa 550-650.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human GTPBP1 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.O00178\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGTPBP1 also called GTP-binding protein 1 plays important roles in cellular processes. It is a member of the GTPase family which hydrolyzes GTP to GDP. GTPBP1 has a mass of about 73 kDa. It is found in various tissues throughout the body with higher expression in the brain liver and testis. GTPBP1 is known to be localized in the cytoplasm and is associated with the ribosome.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGTPBP1 participates in ribosome biogenesis and RNA metabolism being involved in quality control of ribosomal RNA processing. It is part of a complex that aids the maturation and function of ribosomal units. This protein has roles in maintaining ribosomal integrity and ensuring proper translation which are essential for cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nGTPBP1 engages in important processes involved in protein synthesis and mitochondrial function. It interacts with the ribosomal RNA processing pathway and plays a part in mitochondrial biogenesis. Related proteins in these pathways include GTPBP2 another GTP-binding protein involved in similar ribosomal functions and proteins in the mitochondrial fission and fusion dynamics.\u003cbr\u003e\nGTPBP1 has associations with neurodegenerative diseases and immune system disorders. Its dysfunction can contribute to neurodegenerative conditions such as Parkinson's disease. GTPBP1 may interact with proteins like alpha-synuclein which is implicated in Parkinson's pathology. Additionally disruptions in GTPBP1 expression can impact immune system balance potentially leading to autoimmune conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853998411945,"sku":"ab200550","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab200550","provider":"Iright","version":"1.0","type":"link"}