{"product_id":"abcam-ab201172","title":"Abcam, ab201172, Anti-Glutaminyl cyclase antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Glutaminyl cyclase antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Glutaminyl-peptide cyclotransferase aa 150-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Glutaminyl-peptide cyclotransferase aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q16769\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutaminyl cyclase also known by the alternate name 'QC' catalyzes the conversion of glutaminyl residues towards pyroglutamyl formation in proteins. This enzyme weighs around 39 kDa and is distributed across various tissues with significant expression in the brain and secretory tissues. The active site of this enzyme facilitates the cyclization of N-terminal glutaminyl and glutamyl residues influencing protein stability and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme modifies peptide hormones and neuropeptides by enhancing their activity or stability. Glutaminyl cyclase does not usually operate within large protein complexes. However its activity is critical for processing secretory proteins into their mature forms. Modifications by the enzyme often regulate peptide function making it an important player in cellular communication processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nGlutaminyl cyclase plays an important role in the neuroendocrine cascade and protein maturation pathways. This enzyme's activity connects with other proteins like hormone receptors affecting their downstream signaling processes. It also shares connections with proteins involved in the proteolytic processing pathway ensuring maturation and activation of peptide substrates.\u003cbr\u003e\nMalfunction of glutaminyl cyclase associates with Alzheimer's disease and amyloidosis. The enzyme's activity influences accumulation of pyroglutamyl-modified proteins which have links to amyloid plaque formation in Alzheimer's disease. This connection involves amyloid-beta peptides where glutaminyl cyclase enhances the aggregation potential through N-terminal cyclization. Effective modulation of this enzyme’s activity might represent a therapeutic approach for related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854362661033,"sku":"ab201172","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab201172","provider":"Iright","version":"1.0","type":"link"}