{"product_id":"abcam-ab202065","title":"Abcam, ab202065, Anti-HIKESHI antibody [EPR17761]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HIKESHI antibody. Suitable for IP, WB, ICC\/IF, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17761,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHIKESHI also known as C11orf73 functions as a nuclear import carrier for the heat shock protein Hsp70 under stress conditions. This protein weighs approximately 24 kDa and is widely expressed in various human tissues with higher concentrations in the brain testis and liver. Its role involves binding to Hsp70 enabling its translocation into the nucleus where it assists in cell survival during and after thermal and other stress conditions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHIKESHI engages in protecting cells from proteotoxic stress by ensuring the proper functioning of Hsp70 which is not bound to other co-chaperones. It does not heterodimerize but operates independently to import Hsp70 into the nucleus. This nuclear import contributes to cellular homeostasis and stress response mechanisms enhancing the cell's ability to manage damaged proteins and stress-induced protein aggregation.\u003cbr\u003e\nPathways\u003cbr\u003e\nHIKESHI participates in cellular stress response and protein folding pathways. This action connects it with proteins involved in the importin beta pathway which contains various nucleocytoplasmic transport mechanisms. HIKESHI shares functional relationships with importin proteins emphasizing its specialized role in ensuring that only specific proteins like Hsp70 access the nuclear compartment during stress states.\u003cbr\u003e\nHIKESHI influences conditions related to stress responses and degenerative diseases. Dysregulation of HIKESHI can lead to impaired cellular stress responses which are implicated in neurodegenerative disorders such as Alzheimer's disease and other protein misfolding diseases. It has connections with other chaperone-related proteins like those mutated in familial Alzheimer's linking it to broader pathways of cellular stress management and neuroprotection.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850302476457,"sku":"ab202065","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab202065","provider":"Iright","version":"1.0","type":"link"}