{"product_id":"abcam-ab202438","title":"Abcam, ab202438, Anti-RMS1 antibody [EPR20103]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RMS1 antibody. Suitable for WB and reacts with Saccharomyces cerevisiae samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20103,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Saccharomyces cerevisiae,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRMS1 also known as Rhomboid-like protein is a transmembrane serine protease with a molecular mass of approximately 55 kDa. It locates primarily on the inner mitochondrial membrane and is widely expressed across various tissues including the heart brain and liver. RMS1 belongs to the family of rhomboid proteases which perform intramembrane proteolysis. This protease modulates protein processing by cleaving specific substrate proteins within the membrane environment influencing their function and stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein contributes to cellular homeostasis by regulating protein quality control and mitochondrial function. It engages in the organized removal of misfolded or damaged proteins within the mitochondria working as part of multiprotein complexes. RMS1 plays a significant role in the control of a subset of substrates ensuring proteins are maintained in their functional forms or cleared if defective which is critical for cellular metabolism and overall energy production.\u003cbr\u003e\nPathways\u003cbr\u003e\nRMS1 interacts with proteolytic and mitochondrial homeostasis pathways. It participates in a pathway linked with mitochondrial proteostasis closely interacting with other proteins like PARL and PINK1 to ensure mitochondrial quality control. RMS1's proteolytic activity adjusts the protein components within the mitochondria aligning with the cell's metabolic demands and signaling needs which is vital for cell survival and adaptation to stress.\u003cbr\u003e\nDefects or dysregulation of RMS1 have been linked to neurodegenerative conditions such as Parkinson's disease. RMS1 affects and connects with other key proteins involved in these disorders including DJ-1 and PINK1 which are vital for maintaining mitochondrial health. Aberrant function of RMS1 disrupts the meticulously balanced environment of protein turnover in mitochondria leading to the accumulation of harmful protein aggregates and oxidative stress which contributes to neuronal cell death.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850364407977,"sku":"ab202438","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab202438","provider":"Iright","version":"1.0","type":"link"}