{"product_id":"abcam-ab204161","title":"Abcam, ab204161, Recombinant human TPM3 + ROS1 protein","description":"\u003cp\u003eSize: 5µg \/ 10µg\u003cbr\u003e\nRecombinant human TPM3 + ROS1 protein is a Human protein, in the 1 to 258 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;70%, suitable for SDS-PAGE, FuncS, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;70% Densitometry,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, FuncS, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab204161 was determined to be 95 nmol\/min\/mg.,\u003cbr\u003e\nAccession:P06753,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTPM3 (Tropomyosin 3) and ROS1 (c-ros oncogene 1) are two distinct proteins that play important roles in the cell. TPM3 is a component of the actin cytoskeleton and has a molecular weight of about 32 kDa. It is involved in stabilizing actin filaments and is expressed in various tissues particularly in skeletal muscle and non-muscle cells. ROS1 is a receptor tyrosine kinase with a molecular weight of approximately 235 kDa and it functions in transducing extracellular signals into cellular responses. ROS1 is primarily expressed in the brain lung and stomach tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTPM3 participates in muscle contraction by regulating actin-myosin interactions and is important in maintaining cytoskeletal stability and dynamics in non-muscle cells. ROS1 on the other hand acts by initiating signal transduction pathways upon ligand binding leading to cell growth and differentiation. The interplay between these proteins although not involving formation of a complex highlights the importance of structural and signaling cohesion within cellular contexts.\u003cbr\u003e\nPathways\u003cbr\u003e\nTPM3 contributes to the actin cytoskeleton regulation pathway which connects to proteins like myosin and actin. ROS1 is significantly involved in the MAPK\/ERK signaling pathway influencing cell proliferation and survival. Within these pathways ROS1 interacts with proteins such as GRB2 and SHP-2 which facilitate downstream signaling. The functional integration of these pathways highlights the coordination between structural stability and receptor-mediated signaling.\u003cbr\u003e\nAlterations involving TPM3 + ROS1 are implicated in cancers and specific myopathies. ROS1 rearrangements result in oncogenic fusions that drive cancers like non-small cell lung cancer (NSCLC). These fusions often involve proteins such as SDC4 and GOPC affecting tumor growth. TPM3 mutations have been associated with congenital myopathies impacting proteins in the muscle contractile machinery. Understanding these interactions helps to delineate the pathogenesis of these conditions and guides therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843854422185,"sku":"ab204161","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab204161","provider":"Iright","version":"1.0","type":"link"}