{"product_id":"abcam-ab204168","title":"Abcam, ab204168, Anti-GTF2H1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GTF2H1 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GTF2H1 aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GTF2H1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.P32780\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGTF2H1 also known as Transcription Factor IIH Subunit 1 is a protein involved in transcription and DNA repair processes. The protein weighs approximately 71 kDa and consists of 667 amino acids. It functions as a part of the TFIIH complex. GTF2H1 is expressed in various tissues with higher levels observed in actively dividing cells suggesting its significant role in cellular proliferation activities. The protein’s complex interactions are indispensable for several DNA-dependent processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGTF2H1 is a component of the TFIIH complex which has roles in both transcription initiation and nucleotide excision repair (NER). This complex is vital for the accurate transcription of DNA into RNA recognizing transcription factors and facilitating chromatin remodeling. Within NER GTF2H1 participates in unwinding DNA allowing the repair machinery to access damaged regions. Its activity ensures the maintenance of genomic stability which is essential for preventing mutations.\u003cbr\u003e\nPathways\u003cbr\u003e\nGTF2H1 plays significant roles in the transcription initiation pathway and the DNA repair pathway. The protein interacts intricately with other members of the TFIIH complex like XPD and XPB which are helicases that modulate DNA unwinding during transcription and repair. These interactions are essential for coordinating the cellular response to DNA damage and regulating transcription by RNA polymerase II integrating the response with cell cycle control mechanisms.\u003cbr\u003e\nMutations or dysfunctions of GTF2H1 can lead to conditions like xeroderma pigmentosum and trichothiodystrophy. Both disorders are associated with defects in the nucleotide excision repair process. In these conditions proteins like XPD (also a part of TFIIH) are implicated which highlights the critical nature of GTF2H1 in maintaining DNA integrity. Such associations highlight the importance of thorough functional understanding of GTF2H1 in the development of therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854197412009,"sku":"ab204168","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab204168","provider":"Iright","version":"1.0","type":"link"}