{"product_id":"abcam-ab204334","title":"Abcam, ab204334, Anti-SH3TC2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SH3TC2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH3TC2 aa 300-400.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SH3TC2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q8TF17\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSH3TC2 also known as KIAA1985 is a protein primarily involved in signal transduction processes. It possesses a molecular mass of approximately 130 kDa. SH3TC2 is largely expressed in Schwann cells the glial cells that form the myelin sheath around peripheral nerves. The protein contains an SH3 domain and several tetratricopeptide repeat (TPR) domains which facilitate protein-protein interactions necessary for its mechanical function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSH3TC2 plays a critical role in the development and maintenance of the peripheral nervous system. It associates with other proteins to form a complex that is essential for the proper function of Schwann cells. SH3TC2 is involved in cellular activities such as cytoskeletal remodeling and signal transduction contributing to the structural integrity and signaling capabilities of nerve fibers.\u003cbr\u003e\nPathways\u003cbr\u003e\nSH3TC2 interacts in particular in the Rho GTPase signaling pathway. This pathway is important for the regulation of the cytoskeleton impacting cell shape and motility. In this context SH3TC2 works with proteins like Rac1 and Cdc42 which are key Rho GTPase family members that modulate actin dynamics and process extension in Schwann cells. This pathway ensures that Schwann cells can correctly enwrap axons to form functional myelin.\u003cbr\u003e\nSH3TC2 mutations have been linked to Charcot-Marie-Tooth disease type 4C a peripheral neuropathy characterized by demyelination and axonal degeneration. This condition emphasizes the importance of SH3TC2 in maintaining proper nerve function. The protein is connected with PMP22 another myelin-associated protein which also plays a pivotal role in nerve morphology and function. Disruption of this partnership can lead to significant nerve conduction issues highlighting the link between SH3TC2 and peripheral nerve disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854231097513,"sku":"ab204334","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab204334","provider":"Iright","version":"1.0","type":"link"}