{"product_id":"abcam-ab204444","title":"Abcam, ab204444, Anti-PEX5\/PER3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PEX5\/PER3 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PEX5 aa 200-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PEX5 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.P50542\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPEX5 (Peroxisomal Biogenesis Factor 5) also referred to as peroxin-5 functions as a cytosolic receptor for peroxisomal targeting signal 1 (PTS1) proteins. With a mass of approximately 71 kDa PEX5 exhibits widespread expression in various tissues. It facilitates the transport of proteins into peroxisomes which are cellular organelles critical for lipid metabolism and the detoxification of reactive oxygen species. PEX5 achieves this by binding to PTS1-tagged proteins in the cytosol and guiding them to the peroxisomal membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe PEX5 protein plays a significant role in peroxisomal protein import by participating in a transient multi-protein transport complex at the peroxisome membrane. This complex ensures that imported proteins are released into the peroxisomal matrix. PEX5 interacts closely with PEX14 a peroxisomal membrane protein to facilitate the docking of PTS1-carrying proteins. PEX5 is indispensable for maintaining normal peroxisomal function and integrity as it ensures that specific enzymes reach their destination to carry out metabolic processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nPEX5 interacts within the broader lipid metabolism and reactive oxygen species detoxification pathways. It contributes to the proper functioning of enzymes involved in beta-oxidation of fatty acids and plasmalogen synthesis. PEX5 operates in conjunction with the PEX7 receptor which handles the PTS2 pathway helping to manage the trafficking of enzymes important for peroxisomal operations thereby integrating lipid metabolism with cellular homeostasis.\u003cbr\u003e\nMutations in the PEX5 gene often result in peroxisome biogenesis disorders such as Zellweger syndrome which is part of Zellweger spectrum disorders. These conditions manifest due to defects in peroxisomal function leading to neurological impairment and metabolic dysregulation. PEX14 has been identified as a related protein as it cooperates with PEX5 in the peroxisomal matrix protein import pathway. Understanding PEX5’s function and interactions is essential for developing strategies to address these genetic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860523307177,"sku":"ab204444","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab204444","provider":"Iright","version":"1.0","type":"link"}