{"product_id":"abcam-ab204846","title":"Abcam, ab204846, Anti-AIM1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal AIM1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CRYBG1 aa 700-850.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CRYBG1 aa 700-850. The exact immunogen used to generate this antibody is proprietary information.Q9Y4K1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe AIM1 protein also known as Absent In Melanoma 1 has roles in various cellular processes. It is commonly identified in multiple tissues including the skin and the eyes where it contributes to cellular stability and function. AIM1 has a molecular mass of around 69 kilodaltons. Its expression patterns suggest it plays significant roles in cellular microenvironment and differentiation especially in melanocytes and ocular cells. Expression levels may vary affecting cellular activities accordingly.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAIM1 associates with structures that include the cytoskeleton indicating its potential role in maintaining cell shape and motility. It has binding capabilities that aid in cellular assembly processes. AIM1 does not usually operate as part of a larger protein complex but influences intracellular signaling indirectly. Its involvement in cell stability further implies a role in developmental pathways possibly impacting cellular proliferation and differentiation outcomes in melanocytes.\u003cbr\u003e\nPathways\u003cbr\u003e\nAIM1 interacts with signaling pathways related to cellular differentiation and proliferation. It plays a part in the regulation of actin cytoskeleton pathways where it influences cellular architecture and movement. In these pathways proteins like Rho family GTPases may relate to AIM1 impacting downstream signaling events. Such interactions highlight AIM1’s influence on dynamic cellular changes and stability.\u003cbr\u003e\nAIM1 shows links to melanoma and retinal diseases. In melanoma AIM1 expression often changes suggesting it may contribute to the aggressive behavior of melanocytes when dysregulated. Connections to ocular proteins like CRX suggest that AIM1 may also play a part in some retinal degenerative conditions. The protein's influence on cellular structure and signaling makes it a significant target for understanding and potentially treating these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854038061225,"sku":"ab204846","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab204846","provider":"Iright","version":"1.0","type":"link"}