{"product_id":"abcam-ab204902","title":"Abcam, ab204902, Anti-TAGLN3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TAGLN3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TAGLN3 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TAGLN3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9UI15\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTransgelin-3 also known as TAGLN3 is a member of the calponin family of actin-binding proteins. It plays a role in the reorganization of the actin cytoskeleton which is important for cellular movement and shape. TAGLN3 contains 201 amino acids giving it an approximate molecular mass of 22.1 kDa. In terms of expression TAGLN3 is mostly found in neural tissues including the brain where it is associated with the development and function of neurons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAGLN3 influences neural development and synaptic plasticity contributing to communication between neurons. This protein does not typically function as part of larger complexes but it associates closely with cytoskeletal components noting its importance in maintaining neuronal architecture. TAGLN3's effect on actin dynamics supports both the stabilization of neural structures and facilitation of structural plasticity required for learning and memory processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAGLN3 interacts closely with intracellular signaling related to actin-mediated processes. It engages in pathways like the RhoA\/ROCK signaling influencing cell morphology and motility by mediating actin filament assembly. Additionally TAGLN3 exhibits interactions with cofilin a known regulator of actin dynamics suggesting a cooperative role in modulating cytoskeletal rearrangement important for functional changes in neural cells.\u003cbr\u003e\nTAGLN3 has been linked to neurodegenerative conditions and certain types of cancer. Dysregulation of TAGLN3 expression may impact neuronal integrity and has been observed in Alzheimer's disease where it potentially contributes to pathogenesis through altered cytoskeletal dynamics. Furthermore aberrant expression of TAGLN3 in cancer particularly glioblastoma suggests a role in tumor progression. In these conditions TAGLN3 often appears alongside proteins like tau in Alzheimer's and β-catenin in glioblastoma likely influencing disease mechanisms through its interactions with the actin cytoskeleton.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854255902889,"sku":"ab204902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab204902","provider":"Iright","version":"1.0","type":"link"}