{"product_id":"abcam-ab206972","title":"Abcam, ab206972, Anti-Beta Arrestin 2 + Beta Arrestin 1 antibody [EPR22073]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Beta Arrestin 2 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22073,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 86% homology with Beta Arrestin 1.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe proteins Beta Arrestin 1 and Beta Arrestin 2 often referred to as Arrestins are multifunctional adaptors important in G protein-coupled receptor (GPCR) regulation. Beta Arrestin 1 has a mass of approximately 47 kDa while Beta Arrestin 2 is about 45 kDa. These proteins are widely expressed in various tissues and play an important role in GPCR signaling by facilitating receptor desensitization internalization and signaling pathways. Their presence is ubiquitous in the body showing expression in tissues like the brain heart and liver.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese Arrestins participate in signal transduction processes by forming complexes with GPCRs. They serve as scaffolds that can recruit other signaling molecules. This ability to form complexes allows them to mediate downstream signaling pathways impacting cellular responses like cell migration proliferation and apoptosis. They are important in fine-tuning cellular responses and adapting to the external environment.\u003cbr\u003e\nPathways\u003cbr\u003e\nBeta Arrestin 1 and 2 play roles beyond GPCR desensitization involving the mitogen-activated protein kinase (MAPK) pathways and the AKT pathway. They interact with proteins such as ERK1\/2 in the MAPK pathway and are implicated in modulating cellular growth and survival signals. Through these pathways Beta Arrestins integrate and coordinate complex signaling networks essential for diverse cellular functions.\u003cbr\u003e\nBeta Arrestins are relevant to conditions such as heart failure and type 2 diabetes. Their role in GPCR signaling links them to heart failure where abnormal receptor signaling can exacerbate the condition. Additionally in type 2 diabetes alterations in GPCR signaling involving these Arrestins can affect insulin sensitivity. They interact with proteins like G proteins and receptors directly connected to these diseases indicating their significance in pathophysiological processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850208432297,"sku":"ab206972","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab206972","provider":"Iright","version":"1.0","type":"link"}