{"product_id":"abcam-ab209664","title":"Abcam, ab209664, Anti-TRPS1 antibody [EPR16171]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-TRPS1 antibody [EPR16171] (ab209664) is a rabbit monoclonal antibody detecting TRPS1 in  IHC-P . Suitable for  Human . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16171,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-TRPS1 antibody [EPR16171] (ab209664) is a rabbit recombinant monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR16171] also available for your convenience: ab209664, Carrier free -\u003cbr\u003e\nab251509\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRPS1 also known as Trichorhinophalangeal syndrome type I protein is a transcriptional regulator with a molecular weight of approximately 141 kDa. It is expressed in a variety of tissues including bone cartilage and hair follicles. Mechanically TRPS1 functions by binding to specific DNA sequences and regulating the transcription of target genes. This gene encodes a protein that contains GATA-type zinc finger domains which facilitate its role in DNA binding and transcription regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe TRPS1 protein plays a significant role in the development of bone and cartilage as well as the differentiation of hair follicles. It acts independently and does not commonly form a stable complex with other proteins. By influencing the expression of genes involved in these developmental processes TRPS1 contributes to various aspects of skeletal and hair follicle formation. The regulation by TRPS1 is important for the proper growth and maintenance of these tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein TRPS1 is notably involved in bone morphogenesis and development pathways. It interacts with signaling proteins like BMPs (Bone Morphogenetic Proteins) within the bone development pathway to regulate bone and cartilage growth. TRPS1 also communicates with signaling pathways that include proteins such as RUNX2 which are critical for bone formation and regulate the transcriptional activity that drives these processes.\u003cbr\u003e\nDysregulation or mutation of the TRPS1 gene is closely linked to Trichorhinophalangeal Syndrome a condition characterized by distinctive craniofacial and skeletal abnormalities. This association involves altered gene expression impacting bone and cartilage tied to TRPS1's regulation of signaling networks with proteins like BMPR1A. The TRPS1 gene is also linked to certain forms of cancer where its altered function may contribute to tumorigenesis through pathways shared with cancer-related proteins such as SMAD4 influencing cell proliferation and apoptosis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848264798377,"sku":"ab209664","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab209664","provider":"Iright","version":"1.0","type":"link"}