{"product_id":"abcam-ab211419","title":"Abcam, ab211419, Anti-Prickle 2 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Prickle 2 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Prickle-like protein 2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Prickle-like protein 2. The exact immunogen used to generate this antibody is proprietary information.Q7Z3G6,\u003cbr\u003e\nSpecificity:ab211419 is predicted not to cross-react with other Prickle protein family memebers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPrickle 2 also known as PRICKLE2 or prickle-like protein 2 is a member of the prickle family of proteins. This protein weighs around 92 kDa and plays an important role in various cellular processes. It is involved in the planar cell polarity (PCP) signaling pathway and regulates directional signaling in tissues. Prickle 2 shows expression in the central nervous system and other tissues demonstrating a significant role in neural development and maintenance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPrickle 2 engages in the coordination of cell orientation and motility. It is part of the PCP complex which controls asymmetrical cell division and positioning. By participating in this complex Prickle 2 ensures cells align properly within the tissue matrix. It contributes to synaptic formation and function highlighting its involvement in neural connectivity and signaling within the brain.\u003cbr\u003e\nPathways\u003cbr\u003e\nPrickle 2 takes part in the Wnt\/PCP signaling pathway and interacts with key proteins such as Dishevelled and Frizzled. This pathway is essential for proper cell orientation and cytoskeletal rearrangement. Prickle 2 and its associated proteins coordinate to influence neural development strategies and maintain synaptic stability important for neural pathfinding and network establishment.\u003cbr\u003e\nPrickle 2's dysfunction links to neural pathologies like epilepsy and autism spectrum disorders. Alterations in Prickle 2 expression can disrupt the Wnt\/PCP pathway causing improper neuron positioning. Prickle 2 connects with proteins like Dishevelled in these contexts affecting the signaling cascades necessary for normal cognitive and developmental processes. Understanding these connections helps elucidate its role in maintaining neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854064898217,"sku":"ab211419","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab211419","provider":"Iright","version":"1.0","type":"link"}