{"product_id":"abcam-ab211460","title":"Abcam, ab211460, Anti-ANKH antibody - C-terminal","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nRabbit Polyclonal ANKH antibody. C-terminal. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANKH aa 450 to C-terminus conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ANKH aa 450 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9HCJ1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ANKH protein also known as the progressive ankylosis protein homolog has a molecular weight of approximately 53 kDa. ANKH facilitates the transport of inorganic pyrophosphate (PPi) across cell membranes an essential process for mineralization in tissues. It is expressed in a variety of tissues notably in bones and joints. Besides its physiological role ANKH also influences the regulation of PPi levels in extracellular environments which is pivotal for maintaining proper bone and cartilage health.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANKH plays a significant role in maintaining PPi homeostasis. It is not known to be a part of any major protein complex but it plays a vital role in skeletal development and mineral metabolism. By managing the balance of PPi ANKH helps inhibit hydroxyapatite crystal formation a critical step in preventing pathological calcification. Its activity contributes to normal joint function and helps maintain cartilage integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nANKH is intricately involved in the mineralization pathway and the regulation of phosphate metabolism. It interacts with proteins like osteopontin and ankylosis protein to modulate mineral deposition in the extracellular matrix. The pathway’s focus is on balancing phosphate levels important for bone density and structural integrity. This regulation prevents excessive deposition which can lead to calcification-related conditions.\u003cbr\u003e\nANKH mutations are linked to conditions such as chondrocalcinosis and ankylosing spondylitis. These disorders result from impaired PPi transport leading to abnormal calcium pyrophosphate dihydrate crystal deposition in joints. ANKH's interaction with proteins such as osteopontin adds complexity to its involvement in these disorders highlighting its importance in joint health and overall mineral regulation. Proper function of ANKH is therefore essential in sustaining normal physiological bone and joint conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854033309865,"sku":"ab211460","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab211460","provider":"Iright","version":"1.0","type":"link"}